Karyotype refinement by multicolor fluorescence in situ hybridization analysis in 18 patients with acute lymphoblastic leukemia.

نویسندگان

  • Giuseppe Calabrese
  • Tea Taraborelli
  • Donatella Fantasia
  • Paolo Guanciali Franchi
  • Antonio Spadano
  • Giandomenico Palka
چکیده

Eighteen patients with acute lymphoblastic leukemia (ALL) were investigated using spectral karyotyping (SKY), and multicolor fluorescence in situ hybridization (FISH) banding analyses. SKY analysis confirmed previous results in patients with G-banded diploid karyotype. Nevertheless in three out of five patients with two or more chromosomal abnormalities, SKY and multicolor banding methods refined the abnormal karyotypes and revealed cryptic anomalies.

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عنوان ژورنال:
  • Haematologica

دوره 87 8  شماره 

صفحات  -

تاریخ انتشار 2002